Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease
Identifieur interne : 000435 ( Main/Exploration ); précédent : 000434; suivant : 000436Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease
Auteurs : Sophie Ory [France] ; Florence Le Jeune [France] ; Claire Haegelen [France] ; Siobhan Vicente [France] ; Pierre Philippot [Belgique] ; Thibaut Dondaine [France] ; Pierre Jannin [France] ; Sophie Drapier [France] ; Dominique Drapier [France] ; Paul Sauleau [France] ; Marc Vérin [France] ; Julie Péron [Suisse]Source :
- Journal of neuropsychology [ 1748-6653 ] ; 2015.
English descriptors
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Abstract
Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently advanced our understanding of the major role played by this basal ganglion in human emotion. Research indicates that STN DBS can induce modifications in all components of emotion, and neuroimaging studies have shown that the metabolic modifications correlated with these emotional disturbances following surgery are both task- and sensory input-dependent. Nevertheless, to date, these modifications have not been confirmed for all emotional components, notably subjective emotional experience, or feelings. To identify the neural network underlying the modification of feelings following STN DBS, we assessed 16 patients with Parkinson's disease before and after surgery, using both subjective assessments of emotional experience and (18) [F]fluorodeoxyglucose positron emission tomography ((18) FDG-PET). The patients viewed six film excerpts intended to elicit happy, angry, fearful, sad, disgusted, and neutral feelings, and they self-rated the intensity of these feelings. After DBS, there was a significant reduction in the intensity of the disgust feeling. Correlations were observed between decreased disgust experience and cerebral glucose metabolism (FDG uptake) in the bilateral pre-frontal cortices (orbitofrontal, dorsolateral, and inferior frontal gyri), bilateral insula, and right cerebellum. We suggest that the STN contributes to the synchronization process underlying the emergence of feelings.
Url:
DOI: 10.1111/jnp.12094
Affiliations:
- Belgique, France, Suisse
- Canton de Genève, Centre-Val de Loire, Poitou-Charentes, Province du Brabant wallon, Région Bretagne, Région Centre, Région wallonne
- Genève, Louvain-la-Neuve, Poitiers, Rennes, Tours
- Centre Val de Loire Université, Université François-Rabelais de Tours, Université catholique de Louvain, Université de Genève, Université de Poitiers, Université de Rennes 1, Université européenne de Bretagne
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Le document en format XML
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35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.ueb.eu/</ref></desc></org></tutelle><tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"><orgName>CHU Pontchaillou [Rennes]</orgName><desc><address><addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.chu-rennes.fr/</ref></desc></org></tutelle><tutelle active="#struct-357205" type="direct"><org type="institution" xml:id="struct-357205" status="INCOMING"><orgName>Institut des Neurosciences Cliniques de Rennes (INCR)</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-238036" status="VALID"><idno type="IdRef">184043662</idno><idno type="RNSR">201220290G</idno><orgName>Comportement et noyaux gris centraux [Rennes]</orgName><date type="start">2012</date><desc><address><addrLine>Université de Rennes 1 - Campus santé-Villejean - 2, Av Pr Léon Bernard - CS 3431735055 RENNES CEDEX</addrLine><country key="FR"></country></address><ref type="url">http://incr.fr/recherche/23-ea-4712-comportements-et-noyaux-gris-centraux</ref></desc><listRelation><relation name="EA4712" active="#struct-105160" type="direct"></relation><relation active="#struct-108091" type="direct"></relation><relation active="#struct-301327" type="direct"></relation><relation active="#struct-357205" type="direct"></relation></listRelation><tutelles><tutelle name="EA4712" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"><orgName>Université de Rennes 1</orgName><orgName type="acronym">UR1</orgName><desc><address><addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rennes1.fr/</ref></desc></org></tutelle><tutelle active="#struct-108091" type="direct"><org type="institution" xml:id="struct-108091" status="VALID"><orgName>Université européenne de Bretagne</orgName><orgName type="acronym">UEB</orgName><desc><address><addrLine>5 boulevard Laënnec - 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.ueb.eu/</ref></desc></org></tutelle><tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"><orgName>CHU Pontchaillou [Rennes]</orgName><desc><address><addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.chu-rennes.fr/</ref></desc></org></tutelle><tutelle active="#struct-357205" type="direct"><org type="institution" xml:id="struct-357205" status="INCOMING"><orgName>Institut des Neurosciences Cliniques de Rennes (INCR)</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author><author><name sortKey="Peron, Julie" sort="Peron, Julie" uniqKey="Peron J" first="Julie" last="Péron">Julie Péron</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-444911" status="INCOMING"> <orgName>Neuroscience of Emotion and Affective Dynamics</orgName> <orgName type="acronym">NEAD</orgName> <desc> <address> <addrLine>Department of Psychology40 bd du Pont d'Arve1205 GenevaSwitzerland</addrLine> <country key="CH"></country> </address> <ref type="url">http://cms.unige.ch/fapse/neuroemo/</ref> </desc> <listRelation> <relation active="#struct-154620" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-154620" type="direct"><org type="institution" xml:id="struct-154620" status="VALID"> <orgName>Université de Genève</orgName> <orgName type="acronym">UNIGE</orgName> <desc> <address> <addrLine>24 rue du Général-Dufour CH - 1211 Genève 4</addrLine> <country key="CH"></country> </address> <ref type="url">http://www.unige.ch/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>Suisse</country><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName><orgName type="university">Université de Genève</orgName></affiliation></author></analytic><idno type="DOI">10.1111/jnp.12094</idno><series><title level="j">Journal of neuropsychology</title><idno type="ISSN">1748-6653</idno><imprint><date type="datePub">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> cerebellum</term><term> emotion</term><term> feelings</term><term> insula</term><term> orbitofrontal cortex</term><term> subthalamic nucleus</term><term>18[F]fluorodeoxyglucose positron emission tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently advanced our understanding of the major role played by this basal ganglion in human emotion. Research indicates that STN DBS can induce modifications in all components of emotion, and neuroimaging studies have shown that the metabolic modifications correlated with these emotional disturbances following surgery are both task- and sensory input-dependent. Nevertheless, to date, these modifications have not been confirmed for all emotional components, notably subjective emotional experience, or feelings. To identify the neural network underlying the modification of feelings following STN DBS, we assessed 16 patients with Parkinson's disease before and after surgery, using both subjective assessments of emotional experience and (18) [F]fluorodeoxyglucose positron emission tomography ((18) FDG-PET). The patients viewed six film excerpts intended to elicit happy, angry, fearful, sad, disgusted, and neutral feelings, and they self-rated the intensity of these feelings. After DBS, there was a significant reduction in the intensity of the disgust feeling. Correlations were observed between decreased disgust experience and cerebral glucose metabolism (FDG uptake) in the bilateral pre-frontal cortices (orbitofrontal, dorsolateral, and inferior frontal gyri), bilateral insula, and right cerebellum. We suggest that the STN contributes to the synchronization process underlying the emergence of feelings.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li><li>Suisse</li></country><region><li>Canton de Genève</li><li>Centre-Val de Loire</li><li>Poitou-Charentes</li><li>Province du Brabant wallon</li><li>Région Bretagne</li><li>Région Centre</li><li>Région wallonne</li></region><settlement><li>Genève</li><li>Louvain-la-Neuve</li><li>Poitiers</li><li>Rennes</li><li>Tours</li></settlement><orgName><li>Centre Val de Loire Université</li><li>Université François-Rabelais de Tours</li><li>Université catholique de Louvain</li><li>Université de Genève</li><li>Université de Poitiers</li><li>Université de Rennes 1</li><li>Université européenne de Bretagne</li></orgName></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Ory, Sophie" sort="Ory, Sophie" uniqKey="Ory S" first="Sophie" last="Ory">Sophie Ory</name></region><name sortKey="Dondaine, Thibaut" sort="Dondaine, Thibaut" uniqKey="Dondaine T" first="Thibaut" last="Dondaine">Thibaut Dondaine</name><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><name sortKey="Jannin, Pierre" sort="Jannin, Pierre" uniqKey="Jannin P" first="Pierre" last="Jannin">Pierre Jannin</name><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><name sortKey="Vicente, Siobhan" sort="Vicente, Siobhan" uniqKey="Vicente S" first="Siobhan" last="Vicente">Siobhan Vicente</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Philippot, Pierre" sort="Philippot, Pierre" uniqKey="Philippot P" first="Pierre" last="Philippot">Pierre Philippot</name></region></country><country name="Suisse"><region name="Canton de Genève"><name sortKey="Peron, Julie" sort="Peron, Julie" uniqKey="Peron J" first="Julie" last="Péron">Julie Péron</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease
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